Drive thrus are the biggest hassle.
Doug DeMuro recently imported an R32 Skyline into the US, and apparently it hasn't all been roses. No, the car hasn't been giving him any trouble, but the position of its steering wheel has. Right-side drive is apparently quite tricky in the US, especially since DeMuro (like most Americans) has spent his entire life driving on the left side. This video shows you the many struggles that come with right-hand drive, including left turns and drive thrus.
Yes, drive thrus are a huge struggle when you're on the wrong side of the car. However, Doug DeMuro has a clever fix that you'll definitely want to see.